Xia Pu

Xia Pu


I have a background of environmental science, toxicogenomics and computational toxicology. I got my bachelor and PhD degree in School of the Environment, Nanjing University, Nanjing, China. Now I am working as a postdoc in University of Ottawa and Environment Canada. My research interest is to develop novel methodology for chemical toxicity testing and screening using on high-throughput omics approach.

Research project

  • Toxicogenomic assessment of complex chemical signatures in double-crested cormorant embryos from variably contaminated Great Lakes sites
  • Application of highly dynamic omics data into adverse outcome pathway (AOP) network-based chemical assessment.
  • Cross-species comparison of Methylmercury-induced biological pathways using concentration-dependent transcriptomics in human, avian and fish cell lines.
  • Comparison of concentration-dependent transcriptomics of Per and Polyfluoroalkyl Substances (PFASs) in human liver cell lines and liver stem cells.


  • Wang P#, Xia P#, Yang J, Wang Z, Peng Y, Shi W, Villeneuve DL, Yu H, Zhang X. (2018) A Reduced Transcriptome Approach to Assess Environmental Toxicants Using Zebrafish Embryo Test. Environ. Sci. Technol. 52, (2), 821-830. #contributed equally
  • Xia P, Zhang X, Zhang H, Wang P, Tian M, Yu H. (2017) Benchmarking Water Quality from Wastewater to Drinking Waters Using Reduced Transcriptome of Human Cells. Environ. Sci. Technol. 51, (16), 9318-9326.
  • Xia P, Zhang X, Xie Y, Guan M, Villeneuve DL, Yu H. (2016) Functional Toxicogenomic Assessment of Triclosan in Human HepG2 Cells Using Genome-Wide CRISPR-Cas9 Screening. Environ. Sci. Technol. 50, (19), 10682-10692. (Cover paper, ES&T’s Best papers of 2016, ACS Editor’s Choice)
  • Peng Y#, Xia P#, Zhang J, Villeneuve DL, Zhang J, Wang Z, Wei S, Yu H, Zhang X. (2016) Toxicogenomic Assessment of 6-OH-BDE47-Induced Developmental Toxicity in Chicken Embryos. Environ. Sci. Technol. 50, (22), 12493-12503. #contributed equally
  • Zhang X, Xia P, Wang P, Yang J, Baird DJ. (2018) Omics Advances in Ecotoxicology. Environ. Sci. Technol. 52, (7), 3842-3851. (Feature Article)